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MULTIPLE MYELOMA

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Abstract

ÀúÀÚµéÀº ÇϾÇÀÇ °ñµ¿ÅëÀ» ÁÖ¼Ò·Î ³»¿øÇÑ 46¼¼ ¿©ÀÚȯÀÚ¿¡¼­ ÀÓ»ó ¡¤¹æ»ç¼±ÇÐÀû ¹× Á¶Á÷
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1. ÀÓ»óÀûÀ¸·Î ¾çÃø ÇϾÇü ºÎÀ§ÀÇ °£ÇæÀûÀÎ µ¿Åë°ú ÇϼøÀÇ Áö°¢¸¶ºñ, ¼â°ñ°ñÀý·Î ÀÎÇÑ µ¿
Åë°ú ¾ÐÅëÀÌ °üÂûµÇ¾ú´Ù.
2. Ç÷û´Ü¹éÁú Àü±â¿µµ¿¿¡¼­ M-Peak°¡ ³ªÅ¸³µÀ¸¸ç, °úÄ®½·Áõ°ú ÀûÇ÷±¸ ħ°­¼Óµµ°¡ Áõ°¡
ÇÏ¿´À¸³ª, ´¢Áß Bence-Jones´Ü¹éÀº °ËÃâµÇÁö ¾Ê¾Ò´Ù.
3.¹æ»ç¼±ÇÐÀûÀ¸·Î º´¼Ò¿¡ ÀÎÁ¢ÇÑ Ä¡±ÙÀÇ Èí¼ö¿Í ÇÔ²² ¾çÃø ÇϾÇüºÎ, »ó¾Ç°ñ, Èï°ñ, ¼â°ñ
¹× »çÁö µîÀÇ ºÎÀ§¿¡¼­ ´Ù¹ß¼ºÀÇ ¹æ»ç¼±Åõ°ú¼º º´¼ÒµéÀÌ »êÀçµÇ¾î °üÂûµÇ¾ú°í, °ñ ½ºÄµ»ó¿¡
¼­ º´¼ÒºÎÀ§¿¡ ¹æ»ç¼± µ¿À§¿ø¼ÒÀÇ ÁýÀûÀÌ Áõ°¡µÇ¾î °üÂûµÇ¾ú´Ù.
4. Á¶Á÷º´ ¸®ÇÐÀûÀ¸·Î ÇüÁú¼¼Æ÷°¡ dzºÎÇÑ °ú¼¼Æ÷¼º °ñ¼öÀÇ ¼Ò°ßÀ» º¸¿´°í, °ñ¼öÁ¾ ¼¼Æ÷ÀÇ
Áõ½Ä°ú °ÅÇÙ±¸ÀÇ ¼ýÀû Áõ°¡°¡ °üÂûµÇ¾ú´Ù.
#ÃÊ·Ï#
Multiple myeloma is a malignant plasma cell tumor that is thought to originate
proliferation of a single clone of abnormal plasma cell resulting production of a whole
monoclonal paraprotein. The authors experienced a case of multiple myeloma with severe
mandibular osteolytic lesions in 46-year-old female. As a result of careful analysis of
clinical, radiological, histopathological features, and laboratory findings, we diagnosed it
as multiple myeloma, and the following results were obtained:
1. Main clinical symptoms were intermittent dull pain on the mandibular body area,
abnormal sensation of lip and pain due to the fracture on the right clavicle.
2. Laboratory findings revealed M-spike, reversed serum albumin-globulin ratio,
markedly elevated ESR and hypercalcemia.
3. Radiographically, multiple osteolytic punched-out radiolucencies were evident on the
skull, zygoma, jaw bones, ribs, clavicle and upper extremities. Enlarged liver and
incirased uptakes on the lesional sites in RN scan were also observed.
4. Histopathologically, markedly hypercellular marrow with sheets of plasmoblasts and
megakaryocytes were also observed.

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